Landscapes are lovely all year round, but hiking around Aconcagua is possible only in summer. The road across the border to Chile is often blocked by snow in winter. Skiing at Las Leñas is possible from June to October.
Note: flight, boat, train and bus timetables change constantly, so check with relevant companies, or a flight search engine like Skyscanner, first.
There are several flights a day from Buenos Aires to Mendoza City’s airport, as well as a daily circular service which links it with several other Argentine cities - see LAN, Aerolineas Argentinas and Austral. From there, it's another 35-minute drive to the Maipú and Luján de Cuyo regions just south. It’s worth hiring a car if you want to explore the whole of the western region independently, but if you just want to tour the wineries, it’s more relaxing to book a guide and vehicle for a couple of days - or borrow a bike from your hotel!
For information on international travel to Buenos Aires, see our guide on getting to Argentina.